Molecular determinants of differential pore blocking of kidney CLC‐K chloride channels
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چکیده
منابع مشابه
Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.
The highly homologous Cl(-) channels CLC-Ka and CLC-Kb are important for water and salt conservation in the kidney and for the production of endolymph in the inner ear. Mutations in CLC-Kb lead to Bartter's syndrome and mutations in the small CLC-K subunit barttin lead to Bartter's syndrome and deafness. Here we show that CLC-Ka is blocked by the recently identified blocker 2-(p-chlorophenoxy)-...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2004
ISSN: 1469-221X,1469-3178
DOI: 10.1038/sj.embor.7400169